Background: The medical community fails dramatically in the understanding of chronic diseases and development of causal therapies. Statistical associations between vaccinations or infections and autoimmune diseases or a multitude of chronic diseases remains without any scientific rational. The Gulf War illness, with an unexpected high health risk (34%) for military personnel after a manifold of vaccinations, points to the need of a scientific approach different from insufficient linear clonal selection concepts in immunology.Methods: Non-linear dynamics analyzed in time series, phase portraits, and mathematical models.Results: Three different types of chronic diseases, different from lasting acute diseases, are discriminated by Cerebrospinal fluid analysis and nonlinear dynamics. A nonlinear model for a virus-driven chronic disease explains the chronification of the infection, as one of the stable optional states between complete immunity and death. The model also helps create causal therapies and facilitating phase transitions to complete immunity based on individual connectivity in the immune network. Chronic diseases with a sudden change from stable health to a pathological but stable state are phase transitions based on metabolic fluctuations spontaneous or facilitated by external influences (via the immune, endocrine or nervous system). A reduced complexity in diseases is shown by the numerical analysis of time series (e.g., heart rate) or attractor phase portraits. In chronic diseases, with immune system associated pathology, vaccination or infection has to be regarded as a facilitator for a phase transition, like a catalyst, but not as the cause. With this causation we understand why no traces, like causative antigens, are found in Gulf War illness, chronic fatigue syndrome, post lyme syndrome, or the mild encephalitis in schizophrenia.Conclusions: The complexity approach shows why antiviral or antibiotic medications fail in chronic diseases. Disease as an emergent property should be investigated on the phenotype level. Nonlinear analysis of time series of the individual patient gives information not available from group statistics of molecular "multiscale" systems or systems biology. New research perspectives could base on the extended time of registry after vaccinations and should focus on causal therapies, which need financial support, independent from the medical-industrial complex, with its divergent interests.

It is well documented that physical exercise, particularly, intense and unaccustomed eccentric exercise is associated with muscle damage. This micro damage can change sarcomere structure and lead to muscle injury, that known Delayed onset muscle soreness (DOMS). Responses of inflammatory increased due to microscopy trauma, and damage morphological ultra-structural of muscle fibers can causes pain and reducing muscle strength. These phenomena are more common in subjects that participate in sport program for the first time, or return after a gap. Some exercise that causes more muscle pain including resistance, polymeric training, skiing, downhill running and walking. Therapeutic modalities for the prevention and management of DOMS related symptoms are numerous and include, stretching, massage, compression, warm-up, ice massage, oxygen therapy, ultrasound, and exercise. One of the newest theories that clarify DOMS is inflammation theory. Based on this theory, some researcher has used anti-inflammatory storied drug such as dexamethasone, or non-storied drug such as ibuprofen, aspirin, and acetaminophen for attenuating DOMS symptoms. If anti-inflammatory drug could attenuate DOMS symptoms, therefore, theoretically, we can use plant with anti-inflammation characteristic for decreasing and attenuating of DOMS symptoms. In generally, much of plant section has anti-inflammatory property. In this regard, Chamomile plant is considered as an effective and important plant with anti-inflammation property. Chamomile plant has antioxidant and anti-inflammation compounds such as Apigenin Quercetin, terpenoid, alpha bisabolol, Coumarin, patuletin, that can attenuate pain and inflammation by reducing prostaglandin E2, interleukin 6 and factor necrosis tumor alpha concentration. Therefore, it may be used for attenuate pain and inflammation following eccentric exercise.Azarbayajani et al. reported that taking Chamomile plant for 14 day can attenuate pain and muscle inflammation during recovery phase (unpublished data). One of other plant that was used of attenuate inflammation is Cinnamon plant.In traditional medicine, Cinnamon has been used as drug for attenuate pain. Cinnamon is dried skin trunk of tree at scientific name Cinnamomum Zeylanicum. Cinnamon has compounds such as eugenol, felandren, and Safrole. Also, it has other compound such as limonene and linalool, trans Cynthia aldehyde, coumarin, resin, and phenyl propanone compound (Hydroxy cinnamaldehyde) (Maridass). Cinnamaldehyde gives property anti spasm to cinnamon plant.Eugenol can attenuate pain by decreasing inflammation via inhibiting of prostaglandins synthesis. It has been reported that taking cinnamon for two days can attenuate symptoms DOMS. In the investigation, author reported that taking Purslane for six days can decrease symptom DOMS. Regarding studies data; it seems that taking and using plant with anti-inflammation property with an appropriate method to control DOMS. However, to clarify effect of mentioned plant we need to have more studies in these filed.

The incidence of microbial keratitis after Intacs implantation is extremely low and channel infection has been infrequently reported. We present a 23-year-old woman with keratoconus of both eyes who underwent implantation of two intrastromal corneal ring segments (Intacs, KeraVision, Inc., Fremont, CA, USA) in the right eye. After 2.5 months, the patient presented with decreased vision, inflammation, and stromal infiltration at the lower channel site of Intacs. Culture was positive for Escherichia coli. The patient was treated with removing of lower segment of Intacs, and subconjunctival and topical antibiotics. The keratitis resolved, leaving opacity and thinning and mild neovascularization in the lower channel site. Our case report illustrates the risk of microbial keratitis even months after Intacs implantation. It shows need for long-term postoperative attention by both patient and physician.